Skip to content
Unleashing the Power of Retatrutide for Weight Loss
According to the National Library of Medicine, “It is expected that the use of Retatrutide, a triple agonist, will result in significant weight loss among individuals who are obese or overweight. This medication has the potential to revolutionize pharmacotherapy for obesity and overweight in the coming years.”
How is Retatrutide different from Semaglutide or Tirzepatide?
Retatrutide works with three different hormonal pathways whereas Semaglutide interacts with one and Tirzepatide interacts with two.
- Gastric inhibitory polypeptide receptor (GIPR) agonist: As a GIP receptor agonist, Retatrutide enhances appetite suppression and prevents fat accumulation, resulting in decreased energy intake and increased energy expenditure.
- Glucagon-like peptide 1 receptor (GLP-1R) agonist: Retatrutide reduces body weight by improving blood sugar levels via enhanced insulin release from the pancreas and reduced release of glucagon (a hormone that increases blood sugar).
- Glucagon receptor (GR) agonist: Retatrutide decreases glucagon release to improve blood sugar levels, decrease food intake, and increase energy expenditure which ultimately results in weight loss.
How does Retatrutide help with weight loss?
- Slowing the emptying of your stomach after eating to help you feel fuller longer
- Stabilizing post-eating blood sugar spikes, stimulating the release of insulin, and storing away more sugar as glucose
- Impacting glucagon hormone levels to suppress appetite and help you burn more energy
How do I dose Retatrutide?
The initial starting dose for Retatrutide may vary based on medical history and it is best to consult with your physician regarding dosing.
Weeks 1-4: 2mg per week
Weeks 4-8: 4mg per week
Maintenance dose: 8mg or higher
When should I take Retatrutide?
Once per week on the same day of the week.
Resources:
https://www.nejm.org/doi/full/10.1056/NEJMoa2301972
Related articles:
https://wittmerrejuvenationclinic.com/everything-you-need-to-know-about-retatrutide/