An Estradiol (E2) test measures the most potent and abundant form of estrogen in your body. Estradiol is primarily produced by the ovaries in women and in smaller amounts by the testes and adrenal glands in men.
What This Test Measures
Estradiol (E2):
The primary estrogen hormone responsible for development and maintenance of female reproductive tissues, bone health, cardiovascular protection, and brain function. In men, estradiol plays a role in bone health, libido, and brain function.
Reference Ranges
Ranges vary significantly by sex, age, and menstrual phase:
Premenopausal Women (varies by cycle phase):
• Follicular phase: 12.5-166 pg/mL
• Ovulation peak: 85-498 pg/mL
• Luteal phase: 43.8-211 pg/mL
Postmenopausal Women:
• Typically below 30 pg/mL
Men:
• 10-40 pg/mL (optimal range debated; too high or too low can cause symptoms)
Results should always be interpreted by a healthcare provider in context.
Who Should Consider This Test
Women:
• Evaluating irregular or absent menstrual periods
• Investigating symptoms of menopause (hot flashes, night sweats, vaginal dryness)
• Fertility assessment and treatment monitoring
• Monitoring hormone replacement therapy (HRT)
• Evaluating symptoms of estrogen excess or deficiency
• Assessing ovarian function
Men:
• Symptoms of high estrogen (gynecomastia, erectile dysfunction, low libido)
• Monitoring testosterone replacement therapy (TRT)
• Evaluating fertility issues
How It Works
1. Order your test online – no doctor visit required
2. Visit any Quest Diagnostics location nationwide
3. Simple blood draw takes approximately 5 minutes
4. Results delivered to your secure portal within 1-2 business days
Preparation
No fasting required. For women with regular cycles, your healthcare provider may recommend testing on a specific day of your cycle depending on the clinical question.
Related Tests to Consider
• FSH and LH – Evaluate pituitary signaling to ovaries/testes
• Total Estrogens – Measures all forms of estrogen
• Testosterone – Often tested alongside estradiol
• Progesterone – Important for menstrual cycle evaluation
Why Choose Wittmer Rejuvenation Clinic
At $21.75, our Estradiol test is competitively priced compared to typical hospital charges. As a hormone replacement therapy clinic, we understand the importance of accurate hormone testing. We partner with Quest Diagnostics for reliable, CLIA-certified laboratory testing with convenient locations across all 50 states.




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