An SHBG (Sex Hormone-Binding Globulin) test measures the level of a protein that binds to sex hormones, primarily testosterone and estrogen, in your blood. SHBG affects how much of these hormones are available for your tissues to use.
What This Test Measures
Sex Hormone-Binding Globulin (SHBG):
SHBG is a protein produced mainly by the liver. It binds tightly to testosterone, dihydrotestosterone (DHT), and estradiol, making them inactive. Only the unbound (“free”) hormones can enter cells and exert effects.
• High SHBG = Less free hormone available
• Low SHBG = More free hormone available
Reference Ranges
Adult Men: 10-57 nmol/L (varies by age and lab)
Adult Women: 18-144 nmol/L (varies by age, menstrual status, and lab)
Who Should Consider This Test
• Men with normal total testosterone but symptoms of low testosterone
• Women with symptoms of excess androgens (acne, hirsutism) despite normal testosterone
• Those with conditions affecting SHBG:
– Obesity (typically lowers SHBG)
– Type 2 diabetes (typically lowers SHBG)
– Hyperthyroidism (raises SHBG)
– Hypothyroidism (lowers SHBG)
– Liver disease (raises SHBG)
• Anyone getting testosterone tested – SHBG helps interpret results
• Women on oral contraceptives or hormone therapy (which raise SHBG)
• Men on testosterone replacement therapy
Why SHBG Matters
SHBG is crucial for understanding hormone status because:
• A man with normal total testosterone but high SHBG may have low free testosterone and symptoms of deficiency
• A woman with normal total testosterone but low SHBG may have high free testosterone causing symptoms
SHBG also helps calculate free testosterone and bioavailable testosterone when measured alongside total testosterone.
How It Works
1. Order your test online – no doctor visit required
2. Visit any Quest Diagnostics location nationwide
3. Simple blood draw takes approximately 5 minutes
4. Results delivered to your secure portal within 1-2 business days
Preparation
No fasting required.
Related Tests to Consider
• Testosterone, Total – Measure alongside SHBG for complete picture
• Testosterone, Free & Total with SHBG – Comprehensive panel
• Estradiol – Also bound by SHBG
• Thyroid Panel – Thyroid affects SHBG levels
Why Choose Wittmer Rejuvenation Clinic
At $30, our SHBG test is competitively priced. As a hormone replacement therapy clinic, we understand that SHBG is essential for properly interpreting testosterone and estrogen levels. We partner with Quest Diagnostics for reliable, CLIA-certified laboratory testing with convenient locations across all 50 states.
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