A Testosterone, Total, LC/MS, Testosterone, Free (calculated) w/SHBG test is a blood test that measures both the total amount of testosterone in your bloodstream using liquid chromatography-mass spectrometry (LC/MS) technology, as well as the calculated amount of free testosterone in your blood.
There are several reasons why your doctor might order a Testosterone, Total, LC/MS, Testosterone, Free (calculated) w/SHBG test:
Symptoms of low testosterone: Testosterone is an important hormone for both men and women, and low levels can cause a variety of symptoms such as decreased sex drive, fatigue, muscle weakness, and depression.
Evaluation of certain medical conditions: Testosterone levels may be affected by certain medical conditions such as polycystic ovary syndrome (PCOS), pituitary gland disorders, and adrenal gland disorders.
Monitoring testosterone replacement therapy: If you are receiving testosterone replacement therapy, your doctor may order a Testosterone, Total, LC/MS, Testosterone, Free (calculated) w/SHBG test to monitor the effectiveness of your treatment.
Evaluation of fertility: In men, low testosterone levels may be a factor in infertility or subfertility.
Measuring both the total and free testosterone levels, along with SHBG levels, can help your doctor determine the cause of any abnormalities in your testosterone levels. Calculated free testosterone is an estimate of the amount of testosterone that is not bound to SHBG, and can provide additional information beyond the total testosterone level alone.
It’s important to note that testosterone levels can vary throughout the day, and multiple tests may be necessary to confirm a diagnosis of low testosterone. Your doctor will consider your specific medical history and symptoms when deciding which tests to order.