Vitamin B Complex Tb syringes #60 + shipping
Vitamin B Complex Tb syringes #60 + shipping
Oxandrolone is an orally-administered synthetic testosterone derivative. Its anabolic effects are greater than its androgenic effects due to the deletion of the methyl group from the C-19 position. The anabolic potency of oxandrolone is approximately 3 to 13 times that of testosterone and methyltestosterone. In combination with adequate calories, oxandrolone is useful for promoting weight gain after burns or trauma and in certain disease states such as COPD and AIDS. The increase in weight is primarily a result of enhanced lean body mass as compared to enhanced body fat often seen with nutritional supplementation. The beneficial effects on lean body mass are lost with drug discontinuance. Oxandrolone is used to help offset protein catabolism associated with prolonged corticosteroid use. Supportive data also exist for the treatment of patients with Duchenne's muscular dystrophy, constitutional delay of growth and puberty, HIV wasting syndrome and associated muscle weakness, and short stature associated with Turner's syndrome. Conflicting evidence exists as to whether or not anabolic steroids significantly increase athletic performance by increasing muscle strength, but the NCAA and IOC currently prohibit their use by athletes. Oxandrolone is not ergogenic at labeled doses but athletes often use higher doses; athletic use should be discouraged due to the risk for dyslipidemia, potential hepatotoxicity, and other serious side effects. Oxandrolone was approved by the FDA in July 1964 and became a controlled substance in 1991.
Clomiphene is a nonsteroidal fertility agent used to induce ovulation in infrequently ovulating or anovulatory women, including patients with polycystic ovary syndrome (PCOS). The drug is effective at producing ovulation in patients with an intact hypothalamic-pituitary-ovarian axis and with ovaries that are capable of functioning normally. Clomiphene is often the first-line agent for these patients due to the relative ease of use and low economic expense. Clomiphene will induce ovulation in 80% of appropriately-chosen patients; roughly 40% will become pregnant within 6 cycles of treatment. Clomiphene is not effective at increasing pregnancy rates in women who spontaneously ovulate on a regular cycle. Clomiphene therapy is associated with only slightly increased rates of multiple births (3—5%) compared to the general population (1%). Multiple gestation, if it occurs, is usually twins. Less than 1% deliver triplets or more. The rate of multiparity with clomiphene as a single-agent is much lower than that which occurs with other fertility agents (e.g., menotropins or FSH). Clomiphene is sometimes used as a diagnostic tool to assess ovarian reserve. It is also administered to regulate the timing of ovulation in those patients receiving donor insemination. Interestingly, clomiphene has been used to increase sperm counts in male patients with idiopathic oligospermia. The FDA first approved clomiphene in 1967.
Sermorelin is the structurally truncated analog of Growth Hormone Releasing Hormone (GHRH). It consists of the first 29 amino acids of the naturally occurring neurohormone that is produced in the hypothalamus.1 Sermorelin is the most widely used member of the GHRH analogue drug class. It can significantly promote the synthesis and release of growth hormone (GH) from cells in the pituitary gland, improving the serum concentrations of GH and subsequently insulin-like growth factor 1 (IGF-1) in animals and humans.23 It is able to influence the concert of hormonal signals that affect GH secretion from the anterior pituitary including GHRH, somatostatin, and insulin like growth factor (IGF) and others. The positive and negative opposing regulation of growth hormone by GHRH and somatostatin, respectively, creates a rhythmic-circadian pattern of GH secretion.4 Thus, modification of both pulse amplitude and frequency of GH secretion results from Sermorelin administration.5 After sermorelin stimulates the release of GH from the pituitary gland, it increases synthesis of IGF-1 in the liver and peripheral tissues.5 Sermorelin acts on the growth hormone releasing hormone receptor (GHRHr) in the pituitary to regulate cellular activities. GHRHr is the natural receptor for the endogenous hormone, GHRH, and for sermorelin. This receptor regulates growth hormone release directly by stimulation and indirectly by a feedback relationships with somatostatin.6 Sermorelin is readily degraded after reaching the bloodstream, having a biological half-life of approximately 10-20 min.7 Due to the biological half-life and bioavailability of Sermorelin, administration for growth in childhood GHD must occur periodically several times a day as subcutaneous-injections.8 However, single daily dosing is sufficient to treat most cases of adult-onset GH insufficiency. Three (3) mcg/kg subcutaneous-injections of Sermorelin have been reported to simulate a naturally occurring GHRH mediated GH release responses.9 In addition to increasing production and secretion GHRH also affects sleep patterns by increasing the amount of slow wave sleep (SWS) while augmenting sleep-related GH secretion and reducing cortisol secretion.10 To exert all its beneficial effects, Sermorelin requires a functioning pituitary and a host of peripheral tissues.1112 This is due to the reliance on endogenous receptors controlling hormone secreting glands and tissues. More precisely, functioning growth hormone releasing hormone receptors (GHRHr) are required on somatotrophs in a functioning anterior pituitary.11
Tadalafil is a selective phosphodiesterase (PDE) type 5 inhibitor similar to sildenafil and vardenafil. It is administered orally for the treatment of male erectile dysfunction (ED), pulmonary arterial hypertension (PAH), benign prostatic hypertrophy (BPH), or the concurrent treatment of erectile dysfunction and BPH. Tadalafil does not inhibit prostaglandins as do some agents for treating impotence (e.g., alprostadil). Unlike sildenafil, visual disturbances have not been reported with tadalafil, which is more selective for PDE5 than for PDE6 present in the retina. The duration of action of tadalafil for the treatment of ED (up to 36 hours) appears to be longer than that of sildenafil and vardenafil. Because PDE inhibitors promote erection only in the presence of sexual stimulation, the longer duration of action of tadalafil allows for more spontaneity in sexual activity. According to ED treatment guidelines, oral phosphodiesterase type 5 inhibitors (PDE5 inhibitor) are considered first-line therapy.1 Tadalafil was in phase II trials for the treatment of female sexual dysfunction, however, further investigation was discontinued. FDA approval was granted November 2003 for treatment of male erectile dysfunction (ED), and in January 2008, approval was granted for once daily use without regard to timing of sexual activity. Tadalafil (Adcirca) was FDA approved for the treatment of pulmonary arterial hypertension (PAH) in May 2009. In clinical studies of patients with pulmonary arterial hypertension (PAH), tadalafil-treated patients experienced improved exercise capacity and less clinical worsening compared to placebo. In October 2011, tadalafil received FDA approval for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH) and for the concurrent treatment of erectile dysfunction and BPH.
Human Chorionic Gonadotropin (HCG) is a gonad-stimulating polypeptide hormone, which mimics LH (Luteinizing Hormone) from the pituitary gland to stimulate Leydig cells of the testes to produce testosterone and sperm. However, it shuts down LH production just like testosterone therapy. HCG is produced by the human placenta, a sterile product derived from the urine of pregnant females. When used in conjunction with testosterone replacement therapy (TRT), it can potentiate increases in estradiol, hematocrit, edema and/or acne. Latest data shows that some men on TRT with hCG were able to remain fertile. This medication will arrive in freeze-dried or 'lyophilized' form, along with bacteriostatic water and a mixing syringe to assist with reconstitution prior to injection. Administered via subcutaneous injection once the vial is mixed with diluent (Bacteriostatic water or Sodium Chloride 0.9% and mixing syringe will be provided, needles/syringes for injection are ordered separately).
Nandrolone decanoate, also known as 19-nortestosterone, is an injectable medication that belongs to the group of drugs called class II anabolic androgenic steroids (AAS). The drugs that fall under class II AAS are all known as 19-nortestosterone derivatives; they are all synthetic derivatives of the endogenous male hormone testosterone. The primary role of testosterone in the human male is to aid the development of secondary sexual characteristics (androgenic effects) during puberty and the development as well as maintenance of muscle mass (anabolic effects); drugs, such as Nandrolone decanoate, that fall under the AAS category were synthesized to have more anabolic and less androgenic properties.1 Originally synthesized and described by Birch in 1950, nandrolone is similar in chemical composition and structure to testosterone. The only difference in chemical composition between testosterone and nandrolone is that nandrolone lacks a methyl group at carbon C-19. Due to its demethylation at C-19, nandrolone decanoate has very strong anabolic effects but weak androgenic effects; its anabolic effects are much stronger than testosterone.2 One of the main indications for the clinical use of injectable nandrolone decanoate is in the management of refractory anemia that is not responsive to other treatment modalities; nandrolone triggers the production of erythropoietin by the kidneys, which results in an increased red blood cell mass and volume. Additionally, in patients suffering from chronic wasting diseases such as cancer, nandrolone may promote tissue development with the subsequent building of muscle mass. Nandrolone may also be used in the medical management of postmenopausal women who have osteoporosis.34
Methylcobalamin, or vitamin B12, is a B-vitamin. It is found in a variety of foods such as fish, shellfish, meats, and dairy products. Although methylcobalamin and vitamin B12 are terms used interchangeably, vitamin B12 is also available as hydroxocobalamin, a less commonly prescribed drug product (see Hydroxocobalamin monograph), and methylcobalamin. Methylcobalamin is used to treat pernicious anemia and vitamin B12 deficiency, as well as to determine vitamin B12 absorption in the Schilling test. Vitamin B12 is an essential vitamin found in the foods such as meat, eggs, and dairy products. Deficiency in healthy individuals is rare; the elderly, strict vegetarians (i.e., vegan), and patients with malabsorption problems are more likely to become deficient. If vitamin B12 deficiency is not treated with a vitamin B12 supplement, then anemia, intestinal problems, and irreversible nerve damage may occur. The most chemically complex of all the vitamins, methylcobalamin is a water-soluble, organometallic compound with a trivalent cobalt ion bound inside a corrin ring which, although similar to the porphyrin ring found in heme, chlorophyll, and cytochrome, has two of the pyrrole rings directly bonded. The central metal ion is Co (cobalt). Methylcobalamin cannot be made by plants or by animals; the only type of organisms that have the enzymes required for the synthesis of methylcobalamin are bacteria and archaea. Higher plants do not concentrate methylcobalamin from the soil, making them a poor source of the substance as compared with animal tissues.