Testosterone

Who should take Tadalafil?

Tadalafil (Cialis)

What is Tadalafil?

Tadalafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, tadalafil works by increasing blood flow to the penis to help a man get and keep an erection. Tadalafil is also used to treat the symptoms of an enlarged prostate (benign prostatic hyperplasiaBPH) Tadalafil is a selective phosphodiesterase-5 (PDE5) inhibitor that produces several downstream effects with the most common therapeutic effect being smooth muscle relaxation. 7 Patients may experience ED due to a variety of causes including psychogenic, neurogenic, vasculogenic, iatrogenic, or endocrine.   Benefits of daily use Tadalafil:
  • Improved circulation
  • Ejaculation time
  • Erectile Dysfunction
  • Improved symptoms pertaining to LUTS (Lower Urinary Tract Symptoms)
  • Easier spontaneous sex 
  Who is this for? Men who are experiencing some level of erectile dysfunction (also called sexual impotence) as well as premature ejaculation.    How and when to take:
  • Tadalafil is best to take in the morning or evening and at the same time each day
  • Avoid excessive or chronic alcohol consumption. Ingesting excess amounts of alcohol (more than four drinks in a short time) may potentiate the hypotension and dizziness caused by tadalafil.
  • Avoid grapefruit products. Tadalafil is metabolized by CYP3A4, and grapefruit products are CYP3A4 inhibitors; therefore, coadministration may increase serum levels of tadalafil and result in increased hypotension.
  • Take with or without food.
  Background FDA approval was granted in November 2003 for the treatment of male erectile dysfunction (ED), and in January 2008, approval was granted for once daily use without regard to timing of sexual activity. Tadalafil (Adcirca) was FDA approved for the treatment of pulmonary arterial hypertension (PAH) in May 2009. In clinical studies of patients with pulmonary arterial hypertension (PAH), tadalafil-treated patients experienced improved exercise capacity and less clinical worsening compared to placebo. In October 2011, tadalafil received FDA approval for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH) and for the concurrent treatment of erectile dysfunction and BPH.   Who is this not for? Do not take tadalafil if you:
  • Have had an allergic reaction to tadalafil or any other medicines in the past
  • Are taking nitrate medicine for chest pain
  • Have a serious heart and liver problem
  • Have recently had a stroke or heart attack
  • Have low blood pressure or uncontrolled high blood pressure
  • Have ever lost your vision due to reduced blood flow to the eye
  Side effects Back pain; dizziness; flushing; headache; indigestion; muscle aches; nausea; stuffy or runny nose. This list may not describe all possible side effects. Call your healthcare provider immediately if you experience signs of an allergic reaction like skin rash, itching or hives, swelling of the face, lips, or tongue; breathing problems; changes in hearing; changes in vision; chest pain; erection lasting more than 4 hours; fast, irregular heartbeat; seizures.   References https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433372/

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